Clinical

Individuals with PWS are, in many ways, perfect subjects for studying the effectiveness of candidate obesity drugs.[ Read more . . . ]

One of the most troubling features of PWS is the high risk of mental illness in adults with the syndrome. Although a considerable amount has been written on obsessive-compulsive traits, stubbornness and maladaptive behaviors associated with PWS, less is known about the incidence and course of mental illness.[ Read more . . . ]

There's a new paper out in a top journal, Science, on what is may be the first understanding of the underlying molecular basis of features of PWS - The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C -- I've put the link at the end of the message. Here's the lowdown:[ Read more . . . ]

In this paper, the authors looked at cardiovascular structure/function in adults with PWS compared to adults with simple obesity. They were interested in better defining whether/why adults with PWS have detectable and/or different heart problems. [ Read more . . . ]